Prefabrication is now opening a multi-billion dollar global opportunity in construction. Even though prefabrication delivers shorter construction periods and generates less waste than conventional onsite construction, it was not dominant in the construction sector in the past. However, recent technology innovations (like design software and 3D printing) and macroeconomic factors (like the cost structure of construction projects) all favor accelerating growth of prefabrication. How is this changing the value chain and who can benefit from these developments? How will these changes affect the role of construction firms, engineering companies and architects and creates opportunities for new participants, like software companies and OEMs?