The product design and simulation software space is rapidly evolving, thanks to synergistic innovations like 3D printing and increasing computing power. Such synergies have resulted in new design and simulation software technologies that are somewhat overlooked but are too important to miss. This report introduces the technologies with case studies from pure-play software startups, 3D printing unicorns, and midsized and large software corporations. Lux Innovation Grid (LIG) analysis reveals the startup space is full of well-positioned players, although they have different technologies, focuses, and strategies. Companies across the value chain should engage with these software technology developers to see what value they can bring.