Over the past few years, we have seen a few corporate pioneers setting their materials informatics (MI) strategies and expect this trend to continue, if not at an accelerated speed. The data-centric nature gives first-mover advantage to successful earlier adopters. Therefore, a suitable MI strategy is in demand. In this report, we analyze three strategies for corporate players to engage MI: Working with a startup, starting an internal MI initiative, and forming a consortium with your peers. Of the three, the consortium model is the most powerful way to engage MI, and successful consortia could re-set the competitive landscape of the chemical and materials industry.